- Clinicopathologic implication of PD-L1 gene alteration in primary adrenal diffuse large B cell lymphoma
-
Ki Rim Lee, Jiwon Koh, Yoon Kyung Jeon, Hyun Jung Kwon, Jeong-Ok Lee, Jin Ho Paik
-
J Pathol Transl Med. 2022;56(1):32-39. Published online November 16, 2021
-
DOI: https://doi.org/10.4132/jptm.2021.10.05
-
-
3,071
View
-
157
Download
-
1
Web of Science
-
Abstract
PDF
- Background
Primary adrenal (PA) diffuse large B cell lymphoma (DLBCL) was previously reported as an aggressive subset of DLBCL, but its genetic features were not sufficiently characterized. From our previous study of DLBCL with programmed death-ligand 1 (PD-L1) gene alterations, we focused on PD-L1 gene alterations in PA-DLBCL with clinicopathologic implications.
Methods We performed fluorescence in situ hybridization for PD-L1 gene translocation and amplification in PA-DLBCL (n = 18) and comparatively analyzed clinicopathologic characteristics with systemic non-adrenal (NA)-DLBCL (n = 90).
Results PA-DLBCL harbored distinctive features (vs. NADLBCL), including high international prognostic index score (3–5) (72% [13/18] vs. 38% [34/90], p = .007), poor Eastern Cooperative Oncology Group performance score (≥ 2) (47% [7/15] vs. 11% [10/90], p = .003), elevated serum lactate dehydrogenase (LDH) (78% [14/18] vs. 51% [44/87], p = .035) and MUM1 expression (87% [13/15] vs. 60% [54/90], p = .047). Moreover, PA-DLBCL showed frequent PD-L1 gene alterations (vs. NA-DLBCL) (39% [7/18] vs. 6% [5/86], p = .001), including translocation (22% [4/18] vs. 3% [3/87], p = .016) and amplification (17% [3/18] vs. 2% [2/87], p = .034). Within the PA-DLBCL group, PD-L1 gene–altered cases (vs. non-altered cases) tended to have B symptoms (p = .145) and elevated LDH (p = .119) but less frequent bulky disease (≥ 10 cm) (p = .119). In the survival analysis, PA-DLBCL had a poor prognosis for overall survival (OS) and progression-free survival (PFS) (vs. NA-DLBCL; p = .014 and p = .004). Within the PA-DLBCL group, PD-L1 translocation was associated with shorter OS and PFS (p < .001 and p = .012).
Conclusions PA-DLBCL is a clinically aggressive and distinct subset of DLBCL with frequent PD-L1 gene alterations. PD-L1 gene translocation was associated with poor prognosis in PA-DLBCL.
- Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
-
Hyun-Jung Kim, Young Hyeh Ko, Ji Eun Kim, Seung-Sook Lee, Hyekyung Lee, Gyeongsin Park, Jin Ho Paik, Hee Jeong Cha, Yoo-Duk Choi, Jae Ho Han, Jooryung Huh
-
J Pathol Transl Med. 2017;51(4):352-358. Published online June 5, 2017
-
DOI: https://doi.org/10.4132/jptm.2017.03.15
-
-
16,810
View
-
1,036
Download
-
63
Web of Science
-
60
Crossref
-
Abstract
PDF
- Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management.
-
Citations
Citations to this article as recorded by
- Epstein–Barr virus‐positive monoclonal lymphoplasmacytic proliferation associated with neurosyphilis in an immunocompetent patient: A case report
Takashi Hibiya, Kiyotaka Nagahama, Yoshie Matsumoto, Kuniaki Saito, Nobuyoshi Sasaki, Keiichi Kobayashi, Akiyasu Otsu, Teppei Shimasaki, Kengo Takeuchi, Yoshiaki Shiokawa, Motoo Nagane, Junji Shibahara Neuropathology.2024; 44(2): 104. CrossRef - Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing
Xiao-na Wang, Jing Hong, Yong-gen Xu, Pei Zhang, Ying-yu Li, Hong-liang Dou, Hai-ping Li BMC Ophthalmology.2024;[Epub] CrossRef - Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer
Al-Hassan M. Mustafa, Oliver H. Krämer, Lynette Daws Pharmacological Reviews.2023; 75(1): 35. CrossRef - Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in ATG9A
Guowu Hu, Pia J Hauk, Nannan Zhang, Waleed Elsegeiny, Carlos M. Guardia, Amy Kullas, Kevin Crosby, Robin R. Deterding, Michaela Schedel, Paul Reynolds, Jordan K Abbott, Vijaya Knight, Stefania Pittaluga, Mark Raffeld, Sergio D. Rosenzweig, Juan S. Bonifac Autophagy.2023; 19(2): 678. CrossRef - When to suspect inborn errors of immunity in Epstein–Barr virus–related lymphoproliferative disorders
Keith A. Sacco, Luigi D. Notarangelo, Ottavia M. Delmonte Clinical Microbiology and Infection.2023; 29(4): 457. CrossRef - Primary head and neck cancer cell cultures are susceptible to proliferation of Epstein-Barr virus infected lymphocytes
Senyao Shao, Lars Uwe Scholtz, Sarah Gendreizig, Laura Martínez-Ruiz, Javier Florido, Germaine Escames, Matthias Schürmann, Carsten Hain, Leonie Hose, Almut Mentz, Pascal Schmidt, Menghang Wang, Peter Goon, Michael Wehmeier, Frank Brasch, Jörn Kalinowski, BMC Cancer.2023;[Epub] CrossRef - Clinical and genetic characterization of Epstein-Barr virus–associated T/NK-cell lymphoproliferative diseases
Hui Luo, Dan Liu, Wenbing Liu, Jin Jin, Xiaoman Bi, Peiling Zhang, Jia Gu, Miao Zheng, Min Xiao, Xin Liu, Jianfeng Zhou, Qian-Fei Wang Journal of Allergy and Clinical Immunology.2023; 151(4): 1096. CrossRef - Outcomes of programmed death protein-1 inhibitors treatment of chronic active Epstein Barr virus infection: A single center retrospective analysis
Yaxian Ma, Peiling Zhang, Yuhan Bao, Hui Luo, Jiachen Wang, Liang Huang, Miao Zheng Frontiers in Immunology.2023;[Epub] CrossRef - Pathogenesis, treatment and prevention of diseases caused by Epstein–Barr virus
A. G. Rumyantsev Pediatric Hematology/Oncology and Immunopathology.2023; 22(2): 166. CrossRef - Epstein–Barr virus-associated B-cell lymphoproliferative disorder meeting the definition of CAEBV B cell disease: a case report
Yaxian Ma, Yuhan Bao, Miao Zheng BMC Infectious Diseases.2023;[Epub] CrossRef - Unpacking the CNS Manifestations of Epstein-Barr Virus: An Imaging Perspective
N. Soni, M. Ora, R. Singh, P. Mehta, A. Agarwal, G. Bathla American Journal of Neuroradiology.2023; 44(9): 1002. CrossRef - Oncoviruses: Induction of cancer development and metastasis by increasing anoikis resistance
Zahra Sobhi Amjad, Ali Shojaeian, Javid Sadri Nahand, Mobina Bayat, Mohammad Taghizadieh, Mosayeb Rostamian, Farhad Babaei, Mohsen Moghoofei Heliyon.2023; 9(12): e22598. CrossRef - Frequency and association of Epstein-Barr Virus genotype in rheumatoid arthritis patients of Khyber Pakhtunkhwa, Pakistan
Ayesha Munir, Suleman Khan, Sanaullah Khan, Sobia Attaullah, Mehwish Munir, Aisha Saleem, Ijaz Ali, Hideo Kato PLOS ONE.2023; 18(12): e0295124. CrossRef - Successful treatment by using a modified SMILE regimen and autologous hematopoietic stem cell transplantation in a pediatric primary EBV-positive nodular NK/T cell lymphoma patient
Jian Li, Juxin Ye, Yongren Wang, Jun Wang, Yongjun Fang Annals of Hematology.2022; 101(2): 433. CrossRef - Genetic errors of immunity distinguish pediatric nonmalignant lymphoproliferative disorders
Lisa R. Forbes, Olive S. Eckstein, Nitya Gulati, Erin C. Peckham-Gregory, Nmazuo W. Ozuah, Joseph Lubega, Nader K. El-Mallawany, Jennifer E. Agrusa, M. Cecilia Poli, Tiphanie P. Vogel, Natalia S. Chaimowitz, Nicholas L. Rider, Emily M. Mace, Jordan S. Ora Journal of Allergy and Clinical Immunology.2022; 149(2): 758. CrossRef - EBV-positive B-cell ulcerative proliferation in the oral cavity associated with EBV-negative follicular lymphoma in a patient with common variable immunodeficiency: A case report and review of the literature
Waleed A. Alamoudi, Antoine Azar, Stefan K. Barta, Faizan Alawi, Takako I. Tanaka, Eric T. Stoopler, Thomas P. Sollecito Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2022; 133(1): e10. CrossRef - Necrotizing Follicular Lymphoma of the Inguinal Region with Sternbergoid Cells: Clinical–Pathological Features of a Challenging Entity
Federico Scarmozzino, Marco Pizzi, Marta Sbaraglia, Luisa Santoro, Luca Frison, Silvia Nalio, Laura Bonaldi, Livio Trentin, Angelo Paolo Dei Tos Applied Sciences.2022; 12(3): 1290. CrossRef - High percentages of peripheral blood T-cell activation in childhood Hodgkin's lymphoma are associated with inferior outcome
Fengqing Cai, Hui Gao, Zhongsheng Yu, Kun Zhu, Weizhong Gu, Xiaoping Guo, Xiaojun Xu, Hongqiang Shen, Qiang Shu Frontiers in Medicine.2022;[Epub] CrossRef - Case Report of a Novel NFkB Mutation in a Lymphoproliferative Disorder Patient
Khashayar Danandeh, Parnian Jabbari, Elham Rayzan, Samaneh Zoghi, Sepideh Shahkarami, Raul Jimenez Heredia, Ana Krolo, Bibi Shahin Shamsian, Kaan Boztug, Nima Rezaei Endocrine, Metabolic & Immune Disorders - Drug Targets.2022; 22(10): 1040. CrossRef - EBV-associated diseases: Current therapeutics and emerging technologies
Srishti Chakravorty, Behdad Afzali, Majid Kazemian Frontiers in Immunology.2022;[Epub] CrossRef - Clinical features and treatment strategies for post-transplant and iatrogenic immunodeficiency-associated lymphoproliferative disorders
Akihiro Ohmoto, Shigeo Fuji Blood Reviews.2021; 49: 100807. CrossRef - Comparative Study on Epstein-Barr Virus-Positive Mucocutaneous Ulcer and Methotrexate-Associated Lymphoproliferative Disorders Developed in the Oral Mucosa: A Case Series of 10 Patients and Literature Review
Kyoichi Obata, Tatsuo Okui, Sawako Ono, Koki Umemori, Shoji Ryumon, Kisho Ono, Mayumi Yao, Norie Yoshioka, Soichiro Ibaragi, Akira Sasaki Diagnostics.2021; 11(8): 1375. CrossRef - Primary age‐related EBV‐associated effusion‐based lymphoma successfully treated with rituximab and thoracentesis
Justin J. Kuhlman, Muhamad Alhaj Moustafa, Alexander J. Tun, David M. Menke, Han W. Tun, Liuyan Jiang Clinical Case Reports.2021;[Epub] CrossRef - Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
Shimaa Hassan AbdelAziz Soliman, Arturo Orlacchio, Fabio Verginelli Microorganisms.2021; 9(6): 1179. CrossRef - Spontaneous regression of chronic epstein –Barr virus infection-related lymphoproliferative disease
Bharti Kumari, Akshata Rao, ManickaSaravanan Subramanian, AparajitBallav Dey Journal of the Indian Academy of Geriatrics.2021; 17(1): 40. CrossRef - The Pivotal Role of Viruses in the Pathogeny of Chronic Lymphocytic Leukemia: Monoclonal (Type 1) IgG K Cryoglobulinemia and Chronic Lymphocytic Leukemia Diagnosis in the Course of a Human Metapneumovirus Infection
Jérémy Barben, Alain Putot, Anca-Maria Mihai, Jérémie Vovelle, Patrick Manckoundia Viruses.2021; 13(1): 115. CrossRef - B cells in multiple sclerosis — from targeted depletion to immune reconstitution therapies
Maria T. Cencioni, Miriam Mattoscio, Roberta Magliozzi, Amit Bar-Or, Paolo A. Muraro Nature Reviews Neurology.2021; 17(7): 399. CrossRef - Development of Mast Cell and Eosinophil Hyperplasia and HLH/MAS-Like Disease in NSG-SGM3 Mice Receiving Human CD34+ Hematopoietic Stem Cells or Patient-Derived Leukemia Xenografts
Laura J. Janke, Denise M. Imai, Heather Tillman, Rosalinda Doty, Mark J. Hoenerhoff, Jiajie J. Xu, Zachary T. Freeman, Portia Allen, Natalie Wall Fowlkes, Ilaria Iacobucci, Kirsten Dickerson, Charles G. Mullighan, Peter Vogel, Jerold E. Rehg Veterinary Pathology.2021; 58(1): 181. CrossRef - Viral coinfections in COVID‐19
Parisa S. Aghbash, Narges Eslami, Milad Shirvaliloo, Hossein B. Baghi Journal of Medical Virology.2021; 93(9): 5310. CrossRef - Genetic predisposition to lymphomas: Overview of rare syndromes and inherited familial variants
Bartosz Szmyd, Wojciech Mlynarski, Agata Pastorczak Mutation Research/Reviews in Mutation Research.2021; 788: 108386. CrossRef - Acute Epstein‐Barr virus associated haemophagocytosis in an Asian female: What is the diagnosis?
Soumya Ojha, Guiyi Ho, Cheryl X. Q. Lim, Siok B. Ng, Sanjay de Mel American Journal of Hematology.2021; 96(11): 1541. CrossRef - Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases
Xinle Cui, Clifford M. Snapper Frontiers in Immunology.2021;[Epub] CrossRef - Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma
Mostafa F. Mohammed Saleh, Ahmed Kotb, Ghada E. M. Abdallah, Ibrahim N. Muhsen, Riad El Fakih, Mahmoud Aljurf Current Oncology.2021; 28(6): 5480. CrossRef - Intestinal ulcers as an initial finding in EBV-associated lymphoproliferative disorder
Sizhu Wang, Yinghuan Dai, Jie Zhang, Dalian Ou, Chunhui Ouyang, Fanggen Lu Medicine.2020; 99(3): e18764. CrossRef - Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies
Joana R. Lérias, Georgia Paraschoudi, Eric de Sousa, João Martins, Carolina Condeço, Nuno Figueiredo, Carlos Carvalho, Ernest Dodoo, Mireia Castillo-Martin, Antonio Beltrán, Dário Ligeiro, Martin Rao, Alimuddin Zumla, Markus Maeurer Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef - Epstein Barr Virus-associated Pediatric Neoplasms
Mozhgan Hashemieh, Fariba Shirvani Archives of Pediatric Infectious Diseases.2020;[Epub] CrossRef - Novel IRF8 and PD-L1 molecular aberrations in systemic EBV-positive T-cell lymphoma of childhood
Atif Saleem, Rohan Joshi, Li Lei, Lhara Lezama, Shyam S. Raghavan, Nastaran Neishaboori, Mohana Roy, Joe Schroers-Martin, Gregory W. Charville, Christian Kunder, Brent Tan, Beth A. Martin, Yasodha Natkunam Human Pathology: Case Reports.2020; 19: 200356. CrossRef - Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease
Luca Roncati, Beatrice Lusenti, Vincenzo Nasillo, Antonio Manenti Annals of Hematology.2020; 99(8): 1945. CrossRef - Epstein-Barr Virus and the Eye
Emmett T. Cunningham, Manfred Zierhut Ocular Immunology and Inflammation.2020; 28(4): 533. CrossRef - An atypical systemic form of chronic active EBV infection
Neha Gupta, Adam Bagg Leukemia & Lymphoma.2020; 61(12): 3030. CrossRef - A Shared TCR Bias toward an Immunogenic EBV Epitope Dominates in HLA-B*07:02–Expressing Individuals
Louise C. Rowntree, Thi H. O. Nguyen, Carine Farenc, Hanim Halim, Luca Hensen, Jamie Rossjohn, Tom C. Kotsimbos, Anthony W. Purcell, Katherine Kedzierska, Stephanie Gras, Nicole A. Mifsud The Journal of Immunology.2020; 205(6): 1524. CrossRef - Chronic active Epstein–Barr virus infection manifesting as coronary artery aneurysm and uveitis
Haijuan Xiao, Bing Hu, Rongmu Luo, Huili Hu, Junmei Zhang, Weiying Kuang, Rui Zhang, Li Li, Gang Liu Virology Journal.2020;[Epub] CrossRef - Epstein-Barr Virus (EBV)-induced B-cell Lymphoproliferative Disorder Mimicking the Recurrence of EBV-associated Hemophagocytic Lymphohistiocytosis
Yuki Yatsushiro, Takuro Nishikawa, Aki Saito, Yozo Nakazawa, Ken-Ichi Imadome, Shunsuke Nakagawa, Yuichi Kodama, Yasuhiro Okamoto, Hirokazu Kanegane, Yoshifumi Kawano Journal of Pediatric Hematology/Oncology.2019; 41(1): e44. CrossRef - Epstein-Barr Virus (EBV)-Related Lymphoproliferative Disorders in Ataxia Telangiectasia: Does ATM Regulate EBV Life Cycle?
Moussab Tatfi, Olivier Hermine, Felipe Suarez Frontiers in Immunology.2019;[Epub] CrossRef - The factors associated with the early diagnosis of nasal NK/T-cell lymphoma with prominent ocular symptoms and general nasal NKTL
Zhen zhen Hu, Ying Wang American Journal of Otolaryngology.2019; 40(3): 353. CrossRef - Unusual lymphoid malignancy and treatment response in two children with Down syndrome
Ashley Geerlinks, Jennifer Keis, Bo Ngan, Amer Shammas, Reza Vali, Johann Hitzler Pediatric Blood & Cancer.2019;[Epub] CrossRef - Extreme Peripheral Blood Plasmacytosis Mimicking Plasma Cell Leukemia as a Presenting Feature of Angioimmunoblastic T-Cell Lymphoma (AITL)
Kelsey Sokol, Saritha Kartan, William T. Johnson, Onder Alpdogan, Neda Nikbakht, Bradley M. Haverkos, Jerald Gong, Pierluigi Porcu Frontiers in Oncology.2019;[Epub] CrossRef - High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments
Hani Nakhoul, Zhen Lin, Xia Wang, Claire Roberts, Yan Dong, Erik Flemington, Blossom Damania mSphere.2019;[Epub] CrossRef - Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization
Granato, Gilardini Montani, Zompetta, Santarelli, Gonnella, Romeo, D’Orazi, Faggioni, Cirone Biomolecules.2019; 9(9): 482. CrossRef - Diffuse Large B-Cell Lymphoma Arising within Ileal Neobladder: An Expanding Spectrum of Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation
Hyekyung Lee, Hyunbin Shin, Nae Yu Kim, Hyun Sik Park, Jinsung Park Cancer Research and Treatment.2019; 51(4): 1666. CrossRef - EBV-associated lymphoproliferative disorder involving the gastrointestinal tract which mimic IBD in immunocompetent patients: case reports and literature review
Yanhua Zhou, Yanlin Zhang, Haiying Zhao, Xuan Cui, Yongqiu Wei, Yongdong Wu, Shutian Zhang, Ye Zong International Journal of Colorectal Disease.2019; 34(11): 1989. CrossRef - Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas
Jungang Chen, Samantha Kendrick, Zhiqiang Qin Viruses.2019; 11(12): 1161. CrossRef - Rapidly Fatal Encephalitis Associated with Atypical Lymphoid Proliferations of the Basal Ganglia Subsequent to Aneurysmal Subarachnoid Hemorrhage
Ayesha Kar, Evin L. Guilliams, Joshua A. Cuoco, Eric A. Marvin Clinics and Practice.2019; 9(4): 1187. CrossRef - Clinicopathologic features of adult EBV-associated B-cell lymphoproliferative disease
Sonja Wörner, Hans-Konrad Mueller-Hermelink, Hans-Ullrich Voelker Pathology - Research and Practice.2018; 214(2): 207. CrossRef - Primary Intestinal Epstein–Barr Virus-associated Natural Killer/T-cell Lymphoproliferative Disorder: A Disease Mimicking Inflammatory Bowel Disease
Zhujun Wang, Wenyan Zhang, Chengxin Luo, Min Zhu, Yu Zhen, Jingxi Mu, Yan Zhang, Renwei Hu, Yufang Wang, Zhonghui Wen, Qin Ouyang, Shuyuan Xiao, Hu Zhang Journal of Crohn's and Colitis.2018; 12(8): 896. CrossRef - Downregulation of CD5 and dysregulated CD8+ T‐cell activation
Taizo Wada Pediatrics International.2018; 60(9): 776. CrossRef - Chronic active Epstein-Barr virus infection of T-cell type, systemic form in an African migrant: case report and review of the literature on diagnostics standards and therapeutic options
Maxi Wass, Marcus Bauer, Roald Pfannes, Kerstin Lorenz, Andreas Odparlik, Lutz P Müller, Claudia Wickenhauser BMC Cancer.2018;[Epub] CrossRef - Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy
Edit Porpaczy, Sabrina Tripolt, Andrea Hoelbl-Kovacic, Bettina Gisslinger, Zsuzsanna Bago-Horvath, Emilio Casanova-Hevia, Emmanuelle Clappier, Thomas Decker, Sabine Fajmann, Daniela A. Fux, Georg Greiner, Sinan Gueltekin, Gerwin Heller, Harald Herkner, Gr Blood.2018; 132(7): 694. CrossRef - Gammaherpesviral infections in patients with immunological disorders
Anna Żuk-Wasek, Maciej Przybylski, Natalia Żeber, Grażyna Młynarczyk, Tomasz Dzieciątkowski Postępy Mikrobiologii - Advancements of Microbiology.2018; 57(2): 145. CrossRef - COMPARATIVE ANALYSIS OF SEROLOGICAL MARKERS OF HERPES VIRUSES AND QUANTITATIVE IMMUNOGLOBULINOPATHIES IN PRIMARY PATIENTS WITH ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA
N. G. Chernova, D. S. Tihomirov, N. P. Soboleva, S. A. Mariina, Y. V. Sidorova, M. N. Sinitsyna, V. N. Dvirnyk, S. M. Kulikov, T. A. Tupoleva, E. E. Zvonkov Problems of Virology.2018; 63(4): 171. CrossRef
- Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives
-
Yoon Kyung Jeon, Sun Och Yoon, Jin Ho Paik, Young A Kim, Bong Kyung Shin, Hyun-Jung Kim, Hee Jeong Cha, Ji Eun Kim, Jooryung Huh, Young-Hyeh Ko
-
J Pathol Transl Med. 2017;51(3):224-241. Published online May 10, 2017
-
DOI: https://doi.org/10.4132/jptm.2017.04.09
-
-
15,764
View
-
656
Download
-
9
Web of Science
-
11
Crossref
-
Abstract
PDF
- Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative disease and those which will be implicated in clinical practice in the near future. Specifically, this guideline addresses the clonality test for B- and T-cell proliferative lesions, molecular cytogenetic tests for malignant lymphoma, determination of cell-of-origin in diffuse large B-cell lymphoma, and molecular genetic alterations incorporated in the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Finally, a new perspective on the next-generation sequencing for diagnostic, prognostic, and therapeutic purpose in malignant lymphoma will be summarized.
-
Citations
Citations to this article as recorded by
- Assessment of Bone Marrow Involvement in B‐Cell non‐Hodgkin Lymphoma Using Immunoglobulin Gene Rearrangement Analysis with Next‐Generation Sequencing
Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Chul Won Choi, Ha Nui Kim, Jung Ah Kwon, Soo‐Young Yoon, Jung Yoon Journal of Clinical Laboratory Analysis.2024;[Epub] CrossRef - Thymus and lung mucosa-associated lymphoid tissue lymphoma with adenocarcinoma of the lung: a case report and literature review
Yu Pang, Daosheng Li, Yiqian Chen, Qinqin Liu, Yuheng Wu, Qingliang Teng, Yuyu Liu World Journal of Surgical Oncology.2023;[Epub] CrossRef - Development and implementation of an automated and highly accurate reporting process for NGS-based clonality testing
Sean T. Glenn, Phillip M. Galbo, Jesse D. Luce, Kiersten Marie Miles, Prashant K. Singh, Manuel J. Glynias, Carl Morrison Oncotarget.2023; 14(1): 450. CrossRef - A comparison of capillary electrophoresis and next-generation sequencing in the detection of immunoglobulin heavy chain H and light chain κ gene rearrangements in the diagnosis of classic hodgkin’s lymphoma
Juan-Juan Zhang, Yu-Xin Xie, Li-Lin Luo, Xuan-Tao Yang, Yi-Xing Wang, Yue Cao, Zheng-Bo Long, Wan-Pu Wang Bioengineered.2022; 13(3): 5868. CrossRef - Lymphoproliferative disorder involving body fluid: diagnostic approaches and roles of ancillary studies
Jiwon Koh, Sun Ah Shin, Ji Ae Lee, Yoon Kyung Jeon Journal of Pathology and Translational Medicine.2022; 56(4): 173. CrossRef - Diagnostic Workup of Primary Cutaneous B Cell Lymphomas: A Clinician's Approach
Giulia Tadiotto Cicogna, Martina Ferranti, Mauro Alaibac Frontiers in Oncology.2020;[Epub] CrossRef - Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates
Alexandra C. Hristov, Nneka I. Comfere, Claudia I. Vidal, Uma Sundram Journal of Cutaneous Pathology.2020; 47(11): 1103. CrossRef - Primary lung mucosa-associated lymphoid tissue lymphoma accompanied by multiple sclerosis
Ke-Ke Yu, Lei Zhu, Ji-Kai Zhao, Rui-Ying Zhao, Yu-Chen Han Chinese Medical Journal.2019; 132(13): 1625. CrossRef - Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
Woojoo Lee, Eun Shin, Bo-Hyung Kim, Hyunchul Kim, Riccardo Dolcetti PLOS ONE.2019; 14(11): e0225096. CrossRef - Views of dermatopathologists about clonality assays in the diagnosis of cutaneous T‐cell and B‐cell lymphoproliferative disorders
Nneka Comfere, Uma Sundram, Maria Yadira Hurley, Brian Swick Journal of Cutaneous Pathology.2018; 45(1): 39. CrossRef - A Next-Generation Sequencing Primer—How Does It Work and What Can It Do?
Yuriy O. Alekseyev, Roghayeh Fazeli, Shi Yang, Raveen Basran, Thomas Maher, Nancy S. Miller, Daniel Remick Academic Pathology.2018; 5: 2374289518766521. CrossRef
- Liquid-Based Cytology of Villoglandular Adenocarcinoma of the Cervix: A Report of 3 Cases
-
Younghwa Choi, Haeryoung Kim, Haiyoung Choi, Daehyun Hwang, Gheeyoung Choe, Jin-Haeng Chung, So Yeon Park, Hye Seung Lee, Jin Ho Paik, Hyo Jin Park
-
Korean J Pathol. 2012;46(2):215-220. Published online April 25, 2012
-
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.215
-
-
6,935
View
-
50
Download
-
2
Crossref
-
Abstract
PDF
Villoglandular adenocarcinoma (VGA) is a rare subtype of cervical adenocarcinoma with a more favorable prognosis compared to conventional adenocarcinomas. Although the tumors are usually recognized on colposcopic examination due to the mainly exophytic growth pattern, they may be underdiagnosed as benign lesions by cytology because of their minimal cytologic atypia. We report the liquid-based cytology (LBC) findings of three histologically confirmed VGAs which we have recently identified. They were characterized by hypercellular smears on low-power examination with smooth-bordered three-dimensional papillary fragments. The nuclei were relatively uniform with irregular nuclear membranes. Nucleoli were small but distinct and macronucleoli were also seen. The abnormal architectural patterns such as papillary structures and nuclear overlapping and nuclear hyperchromasia are important clues to the diagnosis of VGA. In addition, nuclear membrane irregularity and prominent nucleoli can be recognized on LBC specimens, further facilitating its diagnosis.
-
Citations
Citations to this article as recorded by
- Villoglandular adenocarcinoma of the uterine cervix: a systematic review and meta-analysis
Anna K. Dietl, Matthias W. Beckmann, Konrad Aumann Archives of Gynecology and Obstetrics.2021; 304(2): 317. CrossRef - Les lésions glandulaires du col utérin : cas no 4
Catherine Genestie, Chiraz Hadj Kacem, Pierre Duvillard Annales de Pathologie.2016; 36(3): 192. CrossRef
|